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Ab Initio studies of receptor interactions with AMPA ((S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl) propionic acid ) and Kainic acid (2S-(2α,3β,4β))-2-carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid

✍ Scribed by Elise Champeil; Gloria Proni; Danielle Sapse

Publisher
Springer-Verlag
Year
2009
Tongue
English
Weight
685 KB
Volume
15
Category
Article
ISSN
1610-2940

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📜 SIMILAR VOLUMES

AMPA receptor agonists: Resolution, conf
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We have previously shown that whereas (RS)-2-amino-3-(3-hydroxy-5-phenylisoxazol-4-yl)propionic acid (APPA) shows the characteristics of a partial agonist at (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors, (S)-APPA is a full AMPA receptor agonist and (R)-APPA a weak

Resolution, configurational assignment,
Resolution, configurational assignment, and enantiopharmacology of 2-amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5-yl)isoxazol-4-yl]propionic acid, a potent GluR3- and GluR4-preferring AMPA receptor agonist
✍ Stine B. Vogensen; Henrik S. Jensen; Tine B. Stensbøl; Karla Frydenvang; Benny B 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 363 KB 👁 2 views

We have previously shown that (RS)-2-amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5-yl)isoxazol-4-yl]propionic acid (2-Me-Tet-AMPA) is a selective agonist at (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors, markedly more potent than AMPA itself, whereas the isomeric com