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A4POE*4-associated Alzheimer's disease risk is modified by α1–antichymotrypsin polymorphism

✍ Scribed by Kamboh, M. Ilyas ;Sanghera, Dharambir K. ;Ferrell, Robert E. ;DeKosky, Steven T.


Book ID
109916707
Publisher
Nature Publishing Group
Year
1995
Tongue
English
Weight
462 KB
Volume
10
Category
Article
ISSN
1061-4036

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A common polymorphism in the α1-antichymotrypsin (ACT) gene has been found to modify the APOE\*4-associated risk of Alzheimer's disease due to an apparent interaction between the two loci. This study was undertaken to determine the gender-and age-related distributions of these two polymorphisms in t