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A versatile synthon approach to the preparation of some phospholipase A2 inhibitors

✍ Scribed by JMC Golec; C.J.R. Hedgecock; P.D. Kennewell

Publisher: Elsevier Science
Year: 1992
Tongue: French
Weight: 204 KB
Volume: 33
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)93992-3

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✦ Synopsis

A versatile route for the preparauon of 2-ketomethylene phosphohplds using &thmne chemistry 1s described Cell membranes contam large amounts of arachldomc acid bound at the 2-poslnon of the membrane phosphohplds Cleavage of arachldomc acid from the 2-position by phosphohpase A, 1s beheved to be a

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