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A versatile method for protein-based antigen bioanalysis in non-clinical pharmacokinetics studies of a human monoclonal antibody drug by an immunoaffinity liquid chromatography–tandem mass spectrometry

✍ Scribed by Onami, Ichio; Ayabe, Miho; Murao, Naoaki; Ishigai, Masaki


Book ID
122296065
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
959 KB
Volume
1334
Category
Article
ISSN
1873-3778

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## Abstract A highly sensitive, rapid assay method has been developed and validated for the estimation of omeprazole (OPZ) in human plasma with liquid chromatography coupled to tandem mass spectrometry with electrospray ionization in the positive‐ion mode. The assay procedure involves alkalinizatio