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A versatile high yield photochemical synthesis of 5-substituted 6-azauracils

โœ Scribed by John S. Swenlon; Robert J. Balchunis

Book ID
112123203
Publisher
Journal of Heterocyclic Chemistry
Year
1974
Tongue
English
Weight
87 KB
Volume
11
Category
Article
ISSN
0022-152X

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Synthesis of some symmetrically substitu
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## Abstract The 3,5โ€bis(5โ€carboxyโ€6โ€azauracilโ€1โ€yl)aniline (**7**) and 1,3,5โ€tris(5โ€carboxyโ€6โ€azauracilโ€1โ€yl)benzene (**10**) were prepared from 3โ€aminoโ€5โ€nitroacetanilide (**1**) __via__ intermediates **2โ€“6**. A series of other substituted 6โ€azauracil derivatives **9, 11โ€14** were also prepared.

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As-Triazine Derivatives with Potential Therapeutic Action. Part 26. Synthesis of 5-Substituted-6-azauracil Acyclonucleosides. -The azauracils (I) are alkylated to give the potential antiviral acyclovir-type nucleoside analogues (III).