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Synthesis of some symmetrically substituted compounds derived from 1,3-bis(6-azauracil-1-yl)benzene and 1,3,5-tris(6-azauracil-1-yl)benzene

✍ Scribed by Petr Bílek; Jan Slouka


Publisher
Journal of Heterocyclic Chemistry
Year
2002
Tongue
English
Weight
49 KB
Volume
39
Category
Article
ISSN
0022-152X

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✦ Synopsis


Abstract

The 3,5‐bis(5‐carboxy‐6‐azauracil‐1‐yl)aniline (7) and 1,3,5‐tris(5‐carboxy‐6‐azauracil‐1‐yl)benzene (10) were prepared from 3‐amino‐5‐nitroacetanilide (1) via intermediates 2–6. A series of other substituted 6‐azauracil derivatives 9, 11‐14 were also prepared.


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## Abstract 5‐Substituted (amine, alkyl, aryl, heterocyclic) 4‐(1,3,4‐thiadiazol‐2‐yl)benzene‐1,3‐ diols were synthesized, and their antifungal properties were examined. The compounds were obtained by the one‐pot reaction of sulfinylbis((2,4‐dihydroxyphenyl)methanethione) with hydrazides or thiosem