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A vector driving the expression of foreign cDNAs in the MHC class II-positive cells of transgenic mice

✍ Scribed by Valérie Kouskoff; Hans-Jorg Fehling; Marianne Lemeur; Christophe Benoist; Diane Mathis


Book ID
118902797
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
380 KB
Volume
166
Category
Article
ISSN
0022-1759

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We have established a gene regulatory system in mice by the inducible anti-sense RNA. We have generated transgenic mice carrying the anti-sense DNA composed of the class II MHC gene under the control of the human metallothionein IIa gene promoter. The detectable amount of anti-sense RNA was constitu