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A variant t(14;17) in acute promyelocytic leukemia Positive response to retinoic acid treatment

โœ Scribed by J.C Cigudosa; M.J Calasanz; M.D Odero; J Marin; E Bengoechea; A Gullon


Book ID
113253395
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
180 KB
Volume
80
Category
Article
ISSN
0165-4608

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Acute promyelocytic leukemia is characterized by the reciprocal translocation of chromosomes 15 and 17. All-trans retinoic acid (ATRA) efficiently induces differentiation of the abnormal promyelocytes. In this study, we had used ATRA as the primary induction therapy for 17 newly diagnosed patients,