A Variant Form of Acute Promyelocytic Leukemia With Marked Myelofibrosis
β Scribed by Kenji Fukuno; Hisashi Tsurumi; Takeshi Yoshikawa; Toshiki Yamada; Masami Oyama; Hisataka Moriwaki
- Publisher
- Carden Jennings Publishing
- Year
- 2001
- Tongue
- English
- Weight
- 92 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0925-5710
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π SIMILAR VOLUMES
Acute promyelocytic leukemia (APL) is usually associated with the translocation t( 15; I7)(q22;q 12-2 I), which disrupts the retinoic acid receptor alpha (RAM) gene on chromosome I7 and the PML gene on chromosome 15. We report a patient with typical APL without the common t( 15; 17). Cytogenetic stu
Early diagnosis of t(15;17) acute promyelocytic leukemia (APL) is essential because of the associated disseminated intravascular coagulation and the unique response of the disease to all-trans retinoic acid (ATRA) therapy. Early diagnosis depends primarily on morphological recognition. The French-Am
## BACKGROUND. Extramedullary involvement is only occasionally observed in patients with acute promyelocytic leukemia (APL) but has been said to occur more frequently after treatment with all-trans retinoic acid (ATRA) than after treatment with cytotoxic drugs. In the literature, 37 well-documented