Acute promyelocytic leukemia with secondary myelofibrosis—Case report and review of the literature
✍ Scribed by Pankhi Dutta; Syed Hasan; Jina Bhattacharyya; Rajat Kumar; Manoranjan Mahapatra; Renu Saxena; Seema Tyagi; Sudha Sazawal; Hara Prasad Pati
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 285 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0361-8609
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Lineage switch from AML to ALL is an extremely rare phenomenon, and we report the case of an adult diagnosed with AML at 46 years of age who relapsed with ALL. At initial diagnosis, blast cell morphology and immunophenotyping were consistent with the diagnosis of M4-AML. Complete remission was achie
## BACKGROUND. Extramedullary involvement is only occasionally observed in patients with acute promyelocytic leukemia (APL) but has been said to occur more frequently after treatment with all-trans retinoic acid (ATRA) than after treatment with cytotoxic drugs. In the literature, 37 well-documented