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Rearrangements of the RARA and PML genes in a cytogenetic variant of acute promyelocytic leukemia

✍ Scribed by Dr. L. Baranger; M. Gardembas; J. Hillion; C. Foussard; N. Ifrah; M. Boasson; R. Berger

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 197 KB
Volume: 6
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870060209

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✦ Synopsis

Acute promyelocytic leukemia (APL) is usually associated with the translocation t( 15; I7)(q22;q 12-2 I), which disrupts the retinoic acid receptor alpha (RAM) gene on chromosome I7 and the PML gene on chromosome 15. We report a patient with typical APL without the common t( 15; 17). Cytogenetic studies demonstrated a normal appearance of chromosomes 15, while a small marker seemed to be an i( 17q-). Molecular analysis showed R A M and PML rearrangements, suggesting that the chromosome abnormality corresponded to a variant translocation. Genes Chrom Cancer 6: I I8-I20 (I 993).

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