Frequent rearrangements of retinoic acid receptor alpha gene and myl gene, and rare mutations of RAS and FMS genes in acute promyelocytic leukemia
β Scribed by Koh Yamamoto; Shinsaku Hirosawa; Hisashi Sakamaki; Nobuo Aoki
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 560 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0361-8609
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π SIMILAR VOLUMES
Acute promyelocytic leukemia (APL) is usually associated with the translocation t( 15; I7)(q22;q 12-2 I), which disrupts the retinoic acid receptor alpha (RAM) gene on chromosome I7 and the PML gene on chromosome 15. We report a patient with typical APL without the common t( 15; 17). Cytogenetic stu
## Abstract ## BACKGROUND The clinical relevance of mutations of the __FMS__βlike tyrosine kinase 3 (__FLT3__) gene in specific cytogenetic subgroups is not clear. The authors examined internal tandem duplication (ITD) and Asp835 mutations of __FLT3__ in patients with acute promyelocytic leukemia