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Frequent rearrangements of retinoic acid receptor alpha gene and myl gene, and rare mutations of RAS and FMS genes in acute promyelocytic leukemia

✍ Scribed by Koh Yamamoto; Shinsaku Hirosawa; Hisashi Sakamaki; Nobuo Aoki


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
560 KB
Volume
40
Category
Article
ISSN
0361-8609

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## Abstract ## BACKGROUND The clinical relevance of mutations of the __FMS__‐like tyrosine kinase 3 (__FLT3__) gene in specific cytogenetic subgroups is not clear. The authors examined internal tandem duplication (ITD) and Asp835 mutations of __FLT3__ in patients with acute promyelocytic leukemia