This paper describes an improved procedure for the reaction of the primary hydroxyl group of 3-O-benzoylceramides with 13-bromoethylphosphoryldichloride and for the subsequent reaction with trimethylamine (fig. 1). Column chromatography of the resulting reaction mixtures gives sphingomyelins and the
A useful synthesis of d-erythro-sphingomyelins
β Scribed by Zhengxin Dong; Jared A. Butcher Jr.
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 205 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
2,4-Di-O-protected Pthreose, readily avaiZabZe from D-galactose, is a versatile intermediate for D-erythro-sphingosine syntheses via trans-selective Wittig reaction, azide introduction at the unprotected hydroxyZic group, and subsequent azide reduction.
D-erythro-sphingosine and D-esythro-sphinganine can be produced in protected form from serine by a synthetic approach in which the normal biological intermediate 3-ketosphinganine in protectyed form, is a key synthetic intermediate. The sequence is short and convergent, proceeds in good overall yiel
D-erythro-Sphingosine 9 is a building block of cerebrosides and glycosphingolipids and was synthesized in 5 steps via an asymmetric aldol addition of the lithiated bislactim ether of cyclo-(L-Val-Gly) 4 to (2E)-hexadecenal(3) in an overall yield of 21 %. I.