Synthesis of D,L-erythro-sphingomyelins

✍ Scribed by H. Alpes

• Publisher: Elsevier Science
• Year: 1974
• Tongue: English
• Weight: 348 KB
• Volume: 13
• Category: Article
• ISSN: 0009-3084
• DOI: 10.1016/0009-3084(74)90025-5

✦ Synopsis

This paper describes an improved procedure for the reaction of the primary hydroxyl group of 3-O-benzoylceramides with 13-bromoethylphosphoryldichloride and for the subsequent reaction with trimethylamine (fig. 1). Column chromatography of the resulting reaction mixtures gives sphingomyelins and the corresponding ceramides in high purity. The procedure is generally applicable for the synthesis of sphingomyelins with saturated, unsaturated, and 2-hydroxy fatty acid chains.