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A useful conversion of alcohols to alkyl fluorides

✍ Scribed by David A Flosser; Roy A Olofson

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
113 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

A useful conversion of alcohols to alkyl fluorides via their fluoroformates is introduced. The fluoroformates are obtained in nearly quantitative yield from the alcohols by treatment with COF 2 (generated in situ from bis(trichloromethyl) carbonate) in ether with KF as an added acid scavenger. The neat fluoroformates are cleaved to the fluorides by heating at 120-125Β°C using hexabutylguanidinium fluoride (HBGF) as the catalyst.

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## Abstract For Abstract see ChemInform Abstract in Full Text.