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A Two-Dimensional Artifact from Asynchronous Decoupling

✍ Scribed by Hugo van Ingen; Geerten W. Vuister; Marco Tessari

Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
101 KB
Volume
156
Category
Article
ISSN
1090-7807

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✦ Synopsis

Many heteronuclear NMR experiments employ decoupling to collapse the heteronuclear multiplet, using decoupling schemes with a periodic phase modulation like WALTZ, MLEV, or GARP. Because of the periodic nature of these schemes, cycling sidebands are generated, whose intensity can be strongly reduced by decoupling asynchronously. We show that the most common implementation of asynchronous decoupling on modern spectrometers is such that the cycling sidebands are subjected to a periodic modulation. For multidimensional experiments, this results in ridges that can seriously compromise the quality of the spectrum. Based on our model, the artifact in a 2D [(1)H]-(15)N NOE equilibrium experiment is simulated and it is shown that the artifact can be prevented by using synchronous decoupling.

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## Abstract Two‐dimensional heteronuclear chemical shift correlation experiments which attempt decoupling in __f__~1~ have been shown to give artifacts in strongly coupled systems. In particular, COLOC and HETRES experiments on methylene groups show an artifact midway between the two proton lines.