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NMR of the methylene group: Artifacts in the proton–proton decoupled heteronuclear two-dimensional chemical shift correlation experiment

✍ Scribed by Alex D. Bain; Donald W. Hughes; Howard N. Hunter

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 369 KB
Volume: 26
Category: Article
ISSN: 0749-1581
DOI: 10.1002/mrc.1260261205

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✦ Synopsis

When the protomproton decoupled heteronuclear two-dimensional chemical shift correlation experiment is applied to a molecule containing methylene groups, the spectra show not only the expected signals at the two proton chemical shifts, but also a strong artifact. This artifact appears at the average of the two proton chemical shifts, and arises from coherence transfer between the two protons caused by the BIRD pulse. It is not caused by strong coupling between the protons, and so may appear in any spectrum. The dependence of this artifact on experimental conditions was analysed, and is illustrated with results obtained on the methylene groups from the cyclophane ring in N,',N,-octamethylenepurinecyclophane. KEY WORDS Two-dimensional NMR Artifacts BIRD pulses Coherence transfer Methylene groups

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