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A transmembrane tail: Interaction of tapasin with TAP and the MHC class I molecule

✍ Scribed by Laura C. Simone; Xiaojian Wang; Joyce C. Solheim


Book ID
116757299
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
255 KB
Volume
46
Category
Article
ISSN
0161-5890

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A major role for tapasin as a stabilizer
✍ Natalio Garbi; Neeraj Tiwari; Frank Momburg; GΓΌnter J. HΓ€mmerling πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 305 KB

Tapasin is a member of the MHC class I loading complex where it bridges the TAP peptide transporter to class I molecules. The main role of tapasin is assumed to be the facilitation of peptide loading and optimization of the peptide cargo. Here, we describe another important function for tapasin. In