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A Critical Role for Tapasin in the Assembly and Function of Multimeric MHC Class I-TAP Complexes

✍ Scribed by Ortmann, B.


Book ID
121158301
Publisher
American Association for the Advancement of Science
Year
1997
Tongue
English
Weight
554 KB
Volume
277
Category
Article
ISSN
0036-8075

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A major role for tapasin as a stabilizer
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Tapasin is a member of the MHC class I loading complex where it bridges the TAP peptide transporter to class I molecules. The main role of tapasin is assumed to be the facilitation of peptide loading and optimization of the peptide cargo. Here, we describe another important function for tapasin. In