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A TMM Cycloaddition Strategy to the Bicyclo[6.3.0]undecyl Ring System. A Total Synthesis of 11-Hydroxyjasionone

✍ Scribed by Trost, Barry M.; Parquette, Jon R.


Book ID
119950857
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
242 KB
Volume
59
Category
Article
ISSN
0022-3263

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The synthesis of a novel prostacyclin analog I has been achieved, incorporating as a key strategic feature a regio-controlled epoxide ring opening (as predicted by MM2 calculations) of a readily available prostaglandin synthon.