A tissue culture model of cartilage breakdown in rheumatoid arthritis
β Scribed by James Steinberg; Soichiro Tsukamoto; Clement B. Sledge
- Publisher
- John Wiley and Sons
- Year
- 1979
- Tongue
- English
- Weight
- 672 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0004-3591
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## Abstract ## Objective To investigate the role of oncostatin M (OSM) in cell adhesion, angiogenesis, and matrix degradation in rheumatoid arthritis (RA) synovial tissue and normal human cartilage. ## Methods Human dermal microvascular endothelial cell (HDMEC) and RA synovial fibroblast (RASF)
Cytogenetic analysis of primary cell cultures and/or passages 1-3 of synovial tissue from seven patients with rheumatoid arthritis was performed. As the only recurrent chromosome aberration, trisomy 7 was found in six of seven cultures. In four cultures, trisomy 7 occurred as a clonal change in up t