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A three-way translocation of MLL, MLLT11, and the novel reciprocal partner gene MYO18A in a child with acute myeloid leukemia

✍ Scribed by Marek Ussowicz; Anna Jaśkowiec; Claus Meyer; Rolf Marschalek; Alicja Chybicka; Tomasz Szczepański; Olga Haus


Book ID
116332673
Publisher
Elsevier
Year
2012
Tongue
English
Weight
447 KB
Volume
205
Category
Article
ISSN
2210-7762

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The MLL gene at 11q23 is frequently disrupted by chromosomal translocations in de novo acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL), and in secondary leukemia induced by treatment with inhibitors of topoisomerase II, including the epipodophylotoxins. The CBFA2 gene at 21q22 is also