## Abstract A facile synthesis for the efficient incorporation of ^14^C or ^13^C into trisubstituted furan compounds has been elaborated. 3βMethylβ4,5,6,7βtetrahydrobenzofuran was prepared in five steps from methylβ and ethylβ2βoxoβ1 cyclohexanecarboxylate with overall yield of 65%. Radioactive lab
A synthetic scheme for the preparation of oxygen labelled furan compounds
β Scribed by Paul W. Jennings; Samuel B. Gingerich
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- French
- Weight
- 407 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0022-2135
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β¦ Synopsis
Abstract
Four alicyclic furan compounds have been synthesized with incorporation of ^18^O in the furan oxygen. Basically, a stable ketonic intermediate of the synthetic scheme was exchanged with H~2~^18^O in THF with a catalytic amount of HCl.
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Starting from acetic acid and methyl iodide an efficient modular synthetic scheme has been developed for the synthesis of 13 C-labeled 2,7-dimethylocta-2,4,6-triene-1,8-dial, which is a suitable building block in the synthesis of carotenoids with tenfold 13 C-enrichment in the central part.
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