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An improved synthetic procedure for the preparation of 195mPt labelled anti-tumour complexes

✍ Scribed by H. Jackson; C. A. McAuliffe; A. Perera; H. L. Sharma; N. J. Tinker

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
453 KB
Volume
29
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

An improved synthetic procedure for the preparation of high specific activity ^195m^Pt labelled cisplatin, carboplatin and iproplatin is reported. The procedure involves synthetic strategies which optimise the yields at each stage of the synthesis, giving products of high purity and in high yield (ie. cisplatin and carboplatin, 43%, and iproplatin, 22%). A new procedure for the synthesis of carboplatin using silver 1,1‐cyclobutanedicarboxylate is also reported.

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