✦ LIBER ✦

A synthetic approach to the tricyclic system of forskolin from D-galactose

✍ Scribed by Issam Hanna; Jean-Yves Lallemand; Philippe Wlodyka

Book ID: 104214686
Publisher: Elsevier Science
Year: 1994
Tongue: French
Weight: 319 KB
Volume: 35
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)73468-x

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✦ Synopsis

The syntksis of tk mkydic system offorskolin by an intramolecular DieleAidcr reaction is described, smrdng from tnQ9-acetyl-D-gakactai.

Forskolln. a highly oxygenated labdane diterpcne, exhibits a broad range of physiological activities through its ability to activate adenylate cyclase. The therapeutic potential of this natural product combined with its highly challenging structure have 8erved to stimulate an impomurt synthetic activity in a munbu of laboratories.l2

In the major@ of the previous synthetic appmachcs, an lnnan~lecular Diels-Akler reaction wa8 selected a8 the key step for the construction of an adequately functionalized AB ring system. In almost all cases, the elaboration of ring C was carried out in the final stage8 of the synthesis. In a new synthetic approach, we

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