A synthesis of the lactone of 5-pyridoxic acid

✍ Scribed by H. M. Wuest; J. A. Bigot; Th. J. de Boer; B. V. D. Wal; J. P. Wibaut

• Book ID: 104586027
• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 164 KB
• Volume: 78
• Category: Article
• ISSN: 0165-0513
• DOI: 10.1002/recl.19590780403

✦ Synopsis

Abstract

The reduction of dimethyl 2‐methyl‐3‐hydroxypyridine 4,5‐dicarboxylate (I) with sodium borohydride and aluminium chloride gives no pyridoxol but a precursor i.e. the lactone II, corresponding to 5‐pyridoxic acid. No isomeric lactone (III) corresponding to 4‐pyridoxic acid was isolated.