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A synthesis of substituted pyrrolidines via a palladium(2+)-catalyzed cyclization. An unusual approach to a carbapenem

โœ Scribed by Trost, Barry M.; Chen, Shyh Fong.


Book ID
124164920
Publisher
American Chemical Society
Year
1986
Tongue
English
Weight
248 KB
Volume
108
Category
Article
ISSN
0002-7863

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An efficient procedure for the synthesis of 2,2-disubstituted benzocyclic ketones by intramolecular carbopalladation of nitriles has been developed. The cyclization of substituted 3-(2-iodoaryl)propanenitriles affords indanones in high yields. The reaction is compatible with a wide variety of functi