A synthesis of (S,S)-(+)-grahamimycin A1
β Scribed by Dario Ghiringhelli
- Book ID
- 104216906
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- French
- Weight
- 218 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
By means of spectral and chemical studies the structure of Grahamimycin Al 1, a novel macrocyclic dilactone antibiotic from Cytospora, is established. As part of a program investigating fungi of the genus Cytospora as a source of novel biologically active substances, we observed that aerobically gro
The title compound is synthesized by use of the easily accessible aldehyde 3 for establishing both chiral centres and of ketenylidentriphenylphosphorane for cyclization. In contrast to literature our product is not an antibiotic. Ronald und Gurusiddaiah 1 berichteten 1980 iiber die Isolierung von (-