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Total synthesis of (-)-grahamimycin A1

โœ Scribed by Hillis, Larry R.; Ronald, Robert C.


Book ID
121425045
Publisher
American Chemical Society
Year
1985
Tongue
English
Weight
618 KB
Volume
50
Category
Article
ISSN
0022-3263

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## Abstract A convergent total synthesis of the antibiotic macrolide myxovirescin A~1~ (1) is described that is largely based on reagentโ€ and catalystโ€controlled transformations. This includes a highly regioselective Negishi reaction of dibromoโ€alkene 48 with an alkynylzinc reagent, and a palladium