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A synthesis of 25-hydroxycholecalciferol-(26, 27-3H)

✍ Scribed by Philip A. Bell; W. Peter Scott

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
293 KB
Volume
9
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of 25‐hydroxycholecaleiferol‐(26, 27‐^3^H) is described. 25‐Oxo‐27‐norcholesta‐5, dien‐3β‐yl acetate is converted photochemically to 25‐oxo‐27‐norcholecalciferol‐3‐acetate, which is then reacted with tritiated methylmagnesium iodide and subsequently saponified to give 25‐hydroxycholecalciferol‐(26, 27‐^3^H).

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