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A study of the influence of hydroxyzine and diazepam on morphine antinociception in the rat

✍ Scribed by Morichi, Riccardo; Pepeu, Giancarlo


Book ID
122171572
Publisher
Elsevier Science
Year
1979
Tongue
English
Weight
541 KB
Volume
7
Category
Article
ISSN
0304-3959

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Pharmacokinetics and pharmacodynamics of
✍ Marianne Ekblom; Marie GΓ₯rdmark; Margareta Hammarlund-Udenaes πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 555 KB

In this study the pharmacokinetics and pharmacodynamics of morphine-3-glucuronide (M3G) were investigated in rats after i.v. administration as a bolus dose (86.7 pmol kg-I) and as a constant rate infusion (2.9 pmol h-') over 5 days. After the bolus dose, the clearance (Cl) was 12.1 ~0.6mlmin-\*\*kg,