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Lack of effect of morphine-3-glucuronide on the spinal antinociceptive actions of morphine in the rat: an electrophysiological study

✍ Scribed by Hewett, Karen; Dickenson, Anthony H.; McQuay, Henry J.

Book ID
123202613
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
540 KB
Volume
53
Category
Article
ISSN
0304-3959

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Pharmacokinetics and pharmacodynamics of
Pharmacokinetics and pharmacodynamics of morphine-3-glucuronide in rats and its influence on the antinociceptive effect of morphine
✍ Marianne Ekblom; Marie GΓ₯rdmark; Margareta Hammarlund-Udenaes πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 555 KB

In this study the pharmacokinetics and pharmacodynamics of morphine-3-glucuronide (M3G) were investigated in rats after i.v. administration as a bolus dose (86.7 pmol kg-I) and as a constant rate infusion (2.9 pmol h-') over 5 days. After the bolus dose, the clearance (Cl) was 12.1 ~0.6mlmin-\*\*kg,