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A study of the frequency of methylation of gene promoter regions in colorectal cancer in the Taiwanese population

✍ Scribed by CHANG-CHIEH WU, JEN-CHUN KUAN, CHIH-HSIUNG HSU, TZU-AN CHEN…

Book ID
120900719
Publisher
Indian Academy of Sciences
Year
2013
Tongue
English
Weight
489 KB
Volume
92
Category
Article
ISSN
0022-1333

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## Abstract Nonrandom, widespread promoter methylation of tumor suppressor genes is a common mechanism of gene inactivation during tumorigenesis. We examined the methylation status of two distinct regions of the __MLH1__ promoter (proximal and distal to the transcription start site) and the __MLH1_