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A Study of alkylation regioselectivity of 5-substituted tetrazoles with chloroacetamides

โœ Scribed by N. T. Pokhodylo; R. D. Savka; V. S. Matiichuk; N. D. Obushak

Book ID
111460529
Publisher
Springer
Year
2010
Tongue
English
Weight
264 KB
Volume
80
Category
Article
ISSN
1070-3632

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Alkylation of 5-substituted tetrazoles
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Regioselective alkylation of 5-substituted-2H-tetrazoles 1 to 2-alkyl derivatives 3 was achieved via decarboxylative alkylation with alkyl cyanoformates. Lesser selectivity was observed with chloroformates.