A stereoselective entry to the fumitremorgins
โ Scribed by Patrick D Bailey; Sean P Hollinshead; Neil R McLay
- Book ID
- 104244993
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 96 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
โฆ Synopsis
The reaction of (L)-tryptophan methyl ester with butynone yields a key cis-l,3-disubstituted-tetrahydro-8-carboline (3), simple
๐ SIMILAR VOLUMES
Using the kinetically controlled Pictet-Spengler reaction, we have developed a three-step, diastereoselective and enantiospecific synthesis of the natural product demethoxy-fumitremorgin C in 21% overall yield.
noeiwd in UIC for pblioation 17 Rbnmry 1975) Recently there has been considerable interest in tremor-producing metabolites from fungi.' We1 and others2 have been interested in a class of tremorgens that formally constitute a combination of tryptophan, proline, mevalonate derived units and oxygen. Ya