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A stereoselective and scalable synthesis of a conformationally constrained S1P1 agonist

โœ Scribed by Shannon R. Fix-Stenzel; Martin E. Hayes; Xiaolei Zhang; Grier A. Wallace; Pintipa Grongsaard; Lisa M. Schaffter; Steven M. Hannick; Thaddeus S. Franczyk; Robert H. Stoffel; Kevin P. Cusack


Book ID
104096569
Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
252 KB
Volume
50
Category
Article
ISSN
0040-4039

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Peptide side chains play critical roles in the event of molecular recognition. In order to study the bioactive conformation of parent peptides, a concise and straightforward five-step synthesis of [5.5]-bicyclic reverse turn dipeptide mimetic scaffolds with side chain functionality at the i+1 and i