A solid-phase total synthesis of the cyclic depsipeptide HDAC inhibitor spiruchostatin A
β Scribed by Yusuke Iijima; Asami Munakata; Kazuo Shin-ya; A. Ganesan; Takayuki Doi; Takashi Takahashi
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- French
- Weight
- 231 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0040-4039
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The halipeptins A (1) and B (2) are two cyclic depsipeptides that were isolated from the sponge Haliclona species by Gomez-Paloma and co-workers. [1,2] Initially, their structures were misassigned as the 17-membered cyclic depsipeptides containing an unusual oxazetidine. [1] One year later the same
Viscosin, a cyclic depsipeptide (containing a peptide lactone) has been prepared by solid-phase chemistry using an Fmoc-protocol starting with an acid sensitive resin. Cyclization with the activating agent BOP-Cl gave a product which was indistinguishable from natural viscosin thereby supporting the