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Solid-phase synthesis of viscosin, a cyclic depsipeptide with antibacterial and antiviral properties

✍ Scribed by Terrence R. Burke Jr.; Martha Knight; Bhaskar Chandrasekhar; James A. Ferretti

Publisher: Elsevier Science
Year: 1989
Tongue: French
Weight: 291 KB
Volume: 30
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)95242-0

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✦ Synopsis

Viscosin, a cyclic depsipeptide (containing a peptide lactone) has been prepared by solid-phase chemistry using an Fmoc-protocol starting with an acid sensitive resin. Cyclization with the activating agent BOP-Cl gave a product which was indistinguishable from natural viscosin thereby supporting the proposed structure.

During the screening of microorganisms for antibiotic substances by Kochi at the Yokohama Medical College, it was

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