A coordination polymer with mixed ligands [Zn 2 (phen) 2 (e,a-cis-1,4-chdc) 2 (H 2 O) 2 ] n (chdcZcyclohexanedicarboxylic acid; phenZ1,10phenanthroline) was prepared under hydrothermal conditions and characterized by elemental analyses, IR spectra, TG analysis, and singlecrystal X-ray diffraction analysis. X-ray crystal structural analyses reveal that 1 and 2 are isomorphic and belong to the monoclinic system. C 40 H 36 Zn 2 N 4 O 10 , P2 1 /c, aZ10.084(2) A ˚, bZ8.9072(18) A ˚, cZ20.276(4) A ˚, bZ99.92(3)8, VZ1793.9(6) A ˚3, ZZ1. In the structures of 1, the 1,4-chdc ligand possesses only one kind of e,a-cis-conformation although there are both cis-and trans-conformations in the raw material. Two oxygen atoms of one carboxyl in 1,4-chdc ligand and another oxygen atom of contraposition carboxyl link adjacent Zn atoms into an infinite 1D zigzag chain. The most attractive structural feature of 1 is that it exhibits an infinite chiral chain-like structure with 2 1 helices along the b-axis. In addition, the right-and left-handed chains are alternate. Meanwhile, the adjacent chains of 1 is linked via hydrogen bonds into 2D network structures, which further form 3D frameworks via p-p interactions of 1,10-phen.