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A single amino acid confers barbiturate sensitivity upon the GABA ρ1 receptor

✍ Scribed by Delia Belelli; Davide Pau; Giulia Cabras; John A Peters; Jeremy J Lambert

Book ID
110004359
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
123 KB
Volume
127
Category
Article
ISSN
0007-1188

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A single amino acid in the second transm
A single amino acid in the second transmembrane domain of GABA ? subunits is a determinant of the response kinetics of GABAC receptors
✍ Qian, Haohua ;Dowling, John E. ;Ripps, Harris 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 132 KB

The subunits that constitute the ␥-aminobutyric acid (GABA) C receptors of retinal neurons form a unique subclass of ligand-gated chloride channels that give rise to sustained GABA-evoked currents that exhibit slow offset (deactivation) kinetics. We exploited this property to examine the molecular m