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The effect of a transmembrane amino acid on etomidate sensitivity of an invertebrate GABA receptor

✍ Scribed by Karen A McGurk; Marco Pistis; Delia Belelli; Anthony G Hope; Jeremy J Lambert


Book ID
110003558
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
365 KB
Volume
124
Category
Article
ISSN
0007-1188

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A single amino acid in the second transm
✍ Qian, Haohua ;Dowling, John E. ;Ripps, Harris πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 132 KB

The subunits that constitute the β₯-aminobutyric acid (GABA) C receptors of retinal neurons form a unique subclass of ligand-gated chloride channels that give rise to sustained GABA-evoked currents that exhibit slow offset (deactivation) kinetics. We exploited this property to examine the molecular m