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A single amino acid in the second transmembrane domain of GABA ρ receptors regulates channel conductance

✍ Scribed by Yujie Zhu; Harris Ripps; Haohua Qian


Book ID
116769508
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
345 KB
Volume
418
Category
Article
ISSN
0304-3940

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A single amino acid in the second transm
✍ Qian, Haohua ;Dowling, John E. ;Ripps, Harris 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 132 KB

The subunits that constitute the ␥-aminobutyric acid (GABA) C receptors of retinal neurons form a unique subclass of ligand-gated chloride channels that give rise to sustained GABA-evoked currents that exhibit slow offset (deactivation) kinetics. We exploited this property to examine the molecular m