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A simplified route to the synthesis of new 99mTc-specific tetradentate ligands

✍ Scribed by Julien Le Gal; Eric Benoist; Marie Gressier; Yvon Coulais; Michèle Dartiguenave

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
175 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis of two new N 2 S 2 or N 2 SO tetradentate ligands and the preparation of their technetium-99m complexes are reported. Each ligand leads to a unique 99m Tc-complex with an excellent radiochemical yield. The in vivo stability of these complexes was determined by serum stability and cysteine challenge studies.

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