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A Simple Synthesis of Nitriles from Aldoximes(1)

✍ Scribed by Singh, Manish K.; Lakshman, Mahesh K.

Book ID
120813471
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
504 KB
Volume
74
Category
Article
ISSN
0022-3263

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An expedient method of Pd-catalyzed conversion of aldoxime into nitrile was developed. The reaction was carried out under the influence of Pd(OAc) 2 /PPh 3 in refluxing CH 3 CN to provide good to high yields. The use of Cs 2 CO 3 (0.1-0.5 equiv) was crucial in some cases.

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