Ultrasound-promoted synthesis of nitriles from aldoximes under ambient conditions

✍ Scribed by Nan Jiang; Arthur J. Ragauskas

• Book ID: 104097992
• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 506 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.06.079

✦ Synopsis

Copper(II) acetate proves to be an active catalyst for ultrasound-promoted conversion of aldoximes into nitriles. This dehydration reaction was carried out in acetonitrile under ambient conditions to provide nitriles with moderate tolerance toward water, which allows one-pot synthesis of a nitrile from an aldehyde with minimal purification.