A new and efficient synthesis of (Β±)-homosarkomycin ethyl ester 6, an antitumor antibiotic is described. The successful synthetic approach to 6 uses b-ketophosphonate 5 as a key intermediate.
β¦ LIBER β¦
A simple synthesis of glycino ethyl ester derivatives of hexachlorocyclotriphosphazene
β Scribed by A. A. Smaardijk; B. de Ruiter; A. A. van der Huizen; J. C. van de Grampel
- Book ID
- 104588442
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 140 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0165-0513
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β¦ Synopsis
Abstract
A general method of preparation is described for glycino ethyl ester derivatives of phosphazeneβlike ring systems, which may serve as precursors for antiβcancer drugs.
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