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A simple synthesis of 2, 6-diaminopimelic-/ 1, 7- 14C/acid

✍ Scribed by A. Arendt; A. Kolodziejczyk

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
152 KB
Volume
9
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A convenient method of synthesis of 2, 6‐diaminopinelic / 1, 7 ^14^C / acid / DAP / has been elaborated. Glutaric aldehyde and K^14^CN produced the dicyanhydrine which was converted without izolation into the dihydantoine derivative of DAP by treatment with NH~4~HCO~3~. Hydrolisis /H~2~So~4~ / and removal of sulphate ions gave the crystalline, chromatographically pure DAP /1, 7‐^14^C/ of spec. activity 4, 42 mCi / mole. The radichemical yield of the synthesis was 56%.

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