A Simple Synthesis of 1,3-Benzoxazin-4-one Derivatives
โ Scribed by Kametani, Tetsuji; Van Loc, Chu; Ihara, Masataka; Fukumoto, Keiichiro
- Book ID
- 118131171
- Publisher
- Japan Institute of Heterocyclic Chemistry
- Year
- 1978
- Tongue
- English
- Weight
- 64 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0385-5414
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The first solid-phase synthesis of 1,4-benzothiazin-3(4H)-ones and 1,4-benzoxazin-3(4H)-ones is reported. Alkylation of the immobilized 4-hydroxy-3-nitrobenzamide 2a and 3-nitro-4-sulfanylbenzamide 2b, followed by reduction and cyclization gave 4. Further alkylation and acylation was performed on th
IJ Some 1,4-dihydre2H-3,1-benzoxa~in-2-one derivatives were synthesized and tested for pharmacological activity. CPhenyl-6-chloro-l,4-dihydro-2H-3,l-benzoxazin-2-one (Compound 4) exhibited anticonvulsant activity against chemically and electrically induced seizures and low acute toxicity in mice. St