✦ LIBER ✦

Synthesis and pharmacological evaluation of 1,4-dihydro-2H-3,1-benzoxazin-2-one derivatives

✍ Scribed by Franco De Marchi; Gian Franco Tamagnone; Mario V. Torrielli

Publisher: John Wiley and Sons
Year: 1971
Tongue: English
Weight: 337 KB
Volume: 60
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600601147

No coin nor oath required. For personal study only.

✦ Synopsis

IJ Some 1,4-dihydre2H-3,1-benzoxa~in-2-one derivatives were synthesized and tested for pharmacological activity. CPhenyl-6-chloro-l,4-dihydro-2H-3,l-benzoxazin-2-one (Compound 4) exhibited anticonvulsant activity against chemically and electrically induced seizures and low acute toxicity in mice. Structure-activity relationships are discussed.

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