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A Simple, Reliable, Catalytic Asymmetric Allylation of Ketones

✍ Scribed by Karen M. Waltz; Jason Gavenonis; Patrick J. Walsh


Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
62 KB
Volume
41
Category
Article
ISSN
0044-8249

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Palladium-Catalyzed Asymmetric Allylic A
✍ Barry M. Trost; Gretchen M. Schroeder πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 390 KB

## Abstract Palladium‐catalyzed asymmetric allylic alkylation of nonstabilized ketone enolates to generate quaternary centers has been achieved in excellent yield and enantioselectivity. Optimized conditions consist of performing the reaction in the presence of two equivalents of LDA as base, one e